Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.62 |
| ▸ | BCR | P11274 | 13/20 | 0.62 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ROR1 | Q01973 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432754 | 1.00 | ABL1 (0.62) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL29514905 | 0.91 | ABL1 (0.63) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL3434563 | 0.91 | ABL1 (0.63) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL29514804 | 0.90 | ABL1 (0.68) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL3431387 | 0.90 | ABL1 (0.68) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL3424826 | 0.89 | KIT (0.71) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL29515033 | 0.89 | KIT (0.71) | ABL1BCRDDR1KITDDR2 | |
| SCHEMBL3435403 | 0.89 | ABL1 (0.79) | ABL1BCRKITFGFR1CYP2C9 | |
| SCHEMBL29514917 | 0.89 | ABL1 (0.79) | ABL1BCRKITFGFR1CYP2C9 | |
| SCHEMBL29514920 | 0.87 | ABL1 (0.65) | ABL1BCRDDR1KITDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3999056-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2022-05-25 | — | — | EP | claimed |
| EP-3999056-A1 | PHARMACEUTICAL COMBINATION AND USE THEREOF | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2022-05-25 | — | — | EP | disclosed |
| CN-112237579-B | Pharmaceutical composition and use thereof | 苏州亚盛药业有限公司 | 2022-03-29 | — | — | CN | disclosed |