Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | PDE9A | O76083 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30721240 | 1.00 | MPL (0.54) | MPLALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL31422773 | 0.89 | MPL (0.47) | MPLALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL5466480 | 0.87 | MPL (0.44) | MPLALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL31273453 | 0.85 | KDM4E (0.50) | MPLALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL30549003 | 0.83 | CFTR (0.52) | MPLALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL5466858 | 0.83 | PTPN1 (0.45) | MPLALDH1A1HPGDMEN1CYP1A2 | |
| SCHEMBL31423182 | 0.80 | KDM4E (0.53) | ALDH1A1HPGDMEN1ALOX12KMT2A | |
| SCHEMBL5114852 | 0.80 | KDM4E (0.53) | ALDH1A1HPGDMEN1ALOX12KMT2A | |
| SCHEMBL31423115 | 0.80 | DAO (0.63) | ALDH1A1HPGDKDM4EHSD17B10POLB | |
| SCHEMBL3643672 | 0.80 | HPGD (0.54) | MPLALDH1A1HPGDMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653102-B2 | Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2014-02-18 | — | — | US | disclosed |