Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 15/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31098194 | 0.84 | RET (0.65) | RET | |
| SCHEMBL25574429 | 0.80 | RET (0.52) | RETCHRM1 | |
| Hydrochloric Acid SCHEMBL25205552 | 0.79 | RET (0.51) | RETCHRM1 | |
| SCHEMBL2698140 | 0.79 | ERN1 (0.50) | METCHRM1ALOX5APFEN1 | |
| SCHEMBL25512077 | 0.76 | RET (0.57) | RET | |
| SCHEMBL22642444 | 0.75 | RET (0.81) | RET | |
| SCHEMBL25209483 | 0.74 | RET (0.52) | RETKITMETCHRM1 | |
| SCHEMBL29516538 | 0.73 | RET (1.00) | RET | |
| SCHEMBL18389991 | 0.73 | RET (1.00) | RET | |
| SCHEMBL18390566 | 0.73 | RET (1.00) | RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349969-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阵列生物制药公司 | 2022-05-10 | — | — | CN | disclosed |