Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 1.00 |
| ▸ | NSD2 | O96028 | 10/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147103 | 1.00 | TTR (1.00) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL30804445 | 1.00 | TTR (1.00) | TTRNSD2AURKAAURKBALDH1A1 | |
| Hydrochloric Acid SCHEMBL28862332 | 0.98 | TTR (0.96) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL2951284 | 0.98 | TTR (0.96) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL28820267 | 0.93 | TTR (0.86) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL1525888 | 0.88 | TTR (0.78) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL29516385 | 0.88 | TTR (0.78) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL150853 | 0.88 | TTR (0.78) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL29363198 | 0.87 | TTR (0.75) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL30233642 | 0.87 | TTR (0.75) | TTRNSD2AURKAAURKBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313959-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E Lifesciences Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204046-A1 | SUBSTITUTED NAPHTHYL P38ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS | GEN1E LIFESCIENCES INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| WO-2022072401-A1 | SMALL MOLECULE INHIBITORS OF CORONAVIRUS ATTACHMENT AND ENTRY, METHODS AND USES THEREOF | UNIVERSITY OF MIAMI (US) | 2022-04-07 | — | — | WO | disclosed |