Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1533879 | 1.00 | KMT2A (1.00) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5192713 | 0.88 | KMT2A (0.78) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL30168472 | 0.86 | KMT2A (0.75) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6039621 | 0.86 | KMT2A (0.75) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL882666 | 0.86 | KMT2A (0.75) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL15286480 | 0.84 | KMT2A (0.73) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7968377 | 0.81 | KMT2A (0.69) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13689274 | 0.81 | KMT2A (0.69) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4225491 | 0.81 | KMT2A (0.69) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13983041 | 0.81 | KMT2A (0.69) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-112004845-B | Resin composition, laminate, semiconductor wafer with resin composition layer, substrate, and semiconductor device | 三菱瓦斯化学株式会社 | 2022-05-31 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |