Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.73 |
| ▸ | TYK2 | P29597 | 17/20 | 0.73 |
| ▸ | JAK2 | O60674 | 13/20 | 0.73 |
| ▸ | JAK3 | P52333 | 11/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28663088 | 1.00 | JAK1 (0.73) | JAK1TYK2JAK2JAK3ALK | |
| SCHEMBL29520351 | 0.87 | JAK1 (0.71) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28654908 | 0.87 | JAK1 (0.71) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL29520648 | 0.84 | JAK1 (1.00) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28659630 | 0.84 | JAK1 (1.00) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28664034 | 0.81 | JAK1 (0.67) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28657664 | 0.80 | JAK1 (0.70) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28666764 | 0.78 | JAK1 (0.70) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28671785 | 0.77 | JAK1 (1.00) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL28654850 | 0.77 | JAK1 (1.00) | JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113461687-B | 2, 8-aza- [4,5] decaspirocyclic ketone derivative and preparation method and application thereof | 四川大学华西医院 | 2022-04-19 | — | — | CN | disclosed |