Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 14/20 | 1.00 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.83 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.83 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.83 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.83 |
| ▸ | CSF1R | P07333 | 2/20 | 0.83 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138732 | 1.00 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138628 | 0.99 | MTOR (0.98) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522256 | 0.99 | MTOR (0.98) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138631 | 0.95 | MTOR (0.91) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522011 | 0.95 | MTOR (0.91) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL31691509 | 0.91 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL135776 | 0.91 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29521841 | 0.91 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL155597 | 0.89 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL154223 | 0.89 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230119470-A1 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY | SIGNAL PHARM LLC (US) | 2023-04-20 | — | — | US | disclosed |
| US-11292796-B2 | Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors | SIGNAL PHARMACEUTICALS, LLC (US) | 2022-04-05 | — | — | US | disclosed |
| CN-106117213-B | Heteroaryl compounds and methods for their synthesis and purification | 西格诺药品有限公司 | 2022-03-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230119470-A1 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY | MTOR, RICTOR, RPTOR | MTOR 1/4885PIK3CA 6/4885RPTOR 3/4885 |
| US-11292796-B2 | Substituted pyrazino[2,3-b]pyrazines as mTOR kinase inhibitors | MTOR, RICTOR, RPTOR | MTOR 1/4885PIK3CA 80/4885RPTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.