Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.56 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.50 |
| ▸ | BTK | Q06187 | 6/20 | 0.50 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TEC | P42680 | 1/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28887501 | 0.92 | JAK3 (0.56) | JAK3JAK1EGFRBTKJAK2 | |
| SCHEMBL29523248 | 0.91 | JAK3 (0.53) | JAK3JAK1EGFRJAK2TYK2 | |
| SCHEMBL28959068 | 0.86 | JAK3 (0.54) | JAK3JAK1EGFRBTKJAK2 | |
| SCHEMBL28887550 | 0.84 | JAK3 (0.57) | JAK3JAK1EGFRBTKJAK2 | |
| SCHEMBL28887548 | 0.83 | JAK3 (0.51) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL29127328 | 0.82 | ACKR3 (0.38) | JAK3JAK1EGFRBTKJAK2 | |
| SCHEMBL28887504 | 0.81 | JAK3 (0.43) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL28887542 | 0.81 | JAK3 (0.53) | JAK3JAK1EGFRBTKJAK2 | |
| SCHEMBL28887569 | 0.81 | JAK3 (0.53) | JAK3JAK1EGFRJAK2TYK2 | |
| SCHEMBL28887503 | 0.81 | TAAR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | claimed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | claimed |
| CN-114292274-B | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114292274-A | Pyrrolo [2,3-d ] pyrimidine derivatives as JAK kinase inhibitors, and preparation method and application thereof | 中国药科大学 | 2022-04-08 | — | — | CN | disclosed |