Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.65 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26970232 | 0.89 | MAP4K1 (0.66) | MAP4K1PTK2MAPK8MAPK9JAK2 | |
| SCHEMBL29526485 | 0.89 | MAP4K1 (0.66) | MAP4K1PTK2MAPK8MAPK9JAK2 | |
| SCHEMBL26970264 | 0.86 | MAP4K1 (0.70) | MAP4K1LRRK2ALK | |
| SCHEMBL29526494 | 0.86 | MAP4K1 (0.70) | MAP4K1LRRK2ALK | |
| SCHEMBL26970189 | 0.83 | LRRK2 (0.66) | MAP4K1LRRK2 | |
| SCHEMBL30689938 | 0.83 | LRRK2 (0.66) | MAP4K1LRRK2 | |
| SCHEMBL29526244 | 0.83 | MAP4K1 (0.59) | MAP4K1PTK2MAPK8MAPK9JAK2 | |
| SCHEMBL26970215 | 0.83 | EGFR (0.67) | MAP4K1PTK2ALK | |
| SCHEMBL29526468 | 0.83 | EGFR (0.67) | MAP4K1PTK2ALK | |
| SCHEMBL29525948 | 0.81 | MAP4K1 (0.60) | MAP4K1PTK2JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240362-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098809-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |