Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21224528 | 0.99 | USP2 (0.41) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL3398818 | 0.86 | NR1H2 (0.43) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL2386023 | 0.86 | NR1H2 (0.43) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL2386027 | 0.86 | NR1H2 (0.43) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL21682785 | 0.86 | NR1H2 (0.50) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL13749174 | 0.86 | NR1H2 (0.49) | USP2SMN1; SMN2NR1H2NR1H3GPR119 | |
| SCHEMBL14829403 | 0.86 | NR1H2 (0.49) | USP2SMN1; SMN2NR1H2NR1H3GPR119 | |
| SCHEMBL14829637 | 0.86 | NR1H2 (0.49) | USP2SMN1; SMN2NR1H2NR1H3GPR119 | |
| SCHEMBL14916072 | 0.85 | CFB (0.42) | USP2SMN1; SMN2NR1H2NR1H3RECQL | |
| SCHEMBL18394698 | 0.85 | NPC1 (0.47) | USP2SMN1; SMN2NR1H2NR1H3RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269748-A | Imidazo [1,2-c ] pyrimidine derivatives as PRC2 inhibitors for the treatment of cancer | 米拉蒂医疗股份有限公司 | 2022-04-01 | — | — | CN | disclosed |