Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.89 |
| ▸ | NPC1 | O15118 | 5/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.89 |
| ▸ | RAB9A | P51151 | 4/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.89 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214477 | 0.94 | KDM4E (0.80) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1605174 | 0.90 | KDM4E (0.74) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1663955 | 0.89 | KDM4E (0.71) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10176157 | 0.88 | KDM4E (0.74) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL29788583 | 0.86 | KDM4E (0.68) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL375580 | 0.86 | KDM4E (0.68) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL214706 | 0.85 | KDM4E (0.68) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30402766 | 0.85 | KDM4E (0.67) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL572541 | 0.85 | KDM4E (0.67) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14662784 | 0.84 | KDM4E (0.66) | KDM4ENPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111406-A2 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | KDM4E 3146/4885NPC1 118/4885ALDH1A1 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.