Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | FOS | P01100 | 2/20 | 0.42 |
| ▸ | JUN | P05412 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29531984 | 0.87 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL3786466 | 0.84 | TSHR (0.46) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3373163 | 0.83 | DYRK1A (0.47) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29531806 | 0.83 | KDM4E (0.45) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7920183 | 0.81 | MAPK1 (0.46) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8326859 | 0.81 | DYRK1A (0.45) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8327180 | 0.81 | DYRK1A (0.45) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6286366 | 0.81 | DYRK1A (0.50) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29810202 | 0.81 | DYRK1A (0.50) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29810196 | 0.81 | MAPK1 (0.46) | KDM4EDYRK1AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081995-A1 | MALT1 MODULATORS AND USES THEREOF | RHEOS MEDICINES, INC. (US) | 2022-04-21 | — | — | WO | disclosed |