Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.56 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344230 | 1.00 | APP (0.56) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL24343978 | 0.81 | APP (0.56) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL14478707 | 0.76 | APP (0.54) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL29353856 | 0.74 | HTT (0.50) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL19785394 | 0.74 | APP (0.48) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL2414177 | 0.73 | APP (0.54) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL17882844 | 0.73 | NPC1 (0.56) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL2413783 | 0.73 | APP (0.54) | APPCNR1CNR2MAOBIDO1 | |
| SCHEMBL20000873 | 0.72 | APP (0.80) | APPMAOBIDO1AGXTSMN1; SMN2 | |
| SCHEMBL12284212 | 0.72 | APP (0.53) | APPCNR1CNR2MAOBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119019388-A | 5-And 6-azaindole compounds for inhibiting Bcr-Abl tyrosine kinase | 英莱汶公司 | 2024-11-26 | — | — | CN | disclosed |
| EP-4225742-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | Enliven Therapeutics, Inc. (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |