Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.72 |
| ▸ | KIT | P10721 | 6/20 | 0.72 |
| ▸ | KDR | P35968 | 5/20 | 0.72 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.72 |
| ▸ | LCK | P06239 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947717 | 0.89 | MAPK14 (0.71) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2944127 | 0.87 | MAPK14 (0.80) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954491 | 0.84 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2948571 | 0.84 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954517 | 0.84 | MAPK14 (0.77) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2945892 | 0.84 | MAPK14 (0.78) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2945618 | 0.84 | MAPK14 (1.00) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952099 | 0.83 | MAPK14 (0.74) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2956864 | 0.82 | MAPK14 (0.95) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954539 | 0.82 | MAPK14 (0.72) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-09-03 | — | — | EP | claimed |
| US-7759337-B2 | Phthalazine compounds and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | claimed |
| EP-1856058-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006094187-A2 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2006-09-08 | — | — | WO | claimed |
| EP-1856058-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-09-03 | — | — | EP | disclosed |