Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.47 |
| ▸ | GRM5 | P41594 | 8/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24629831 | 1.00 | PDK4 (0.54) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL29744827 | 0.87 | PDK4 (0.55) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL19097505 | 0.87 | PDK4 (0.55) | PDK4CNR1HTR6JAK1GRM1 | |
| SCHEMBL1811363 | 0.87 | PDK4 (0.55) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL29744751 | 0.86 | PDK4 (0.54) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL31444034 | 0.86 | PDK4 (0.54) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL31222963 | 0.86 | PDK4 (0.54) | PDK4CNR1HTR6JAK1GRM1 | |
| SCHEMBL6402391 | 0.86 | PDK4 (0.54) | PDK4NR1H2CNR1HTR6JAK1 | |
| SCHEMBL2880379 | 0.86 | GRM1 (0.55) | PDK4CNR1HTR6JAK1GRM1 | |
| SCHEMBL17398182 | 0.85 | PDK4 (0.53) | PDK4NR1H2CNR1HTR6JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| EP-4192458-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | C4 Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022235945-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022150574-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2022-07-14 | — | — | WO | disclosed |
| WO-2022032026-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | C4 THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |