Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.39 |
| ▸ | PTAFR | P25105 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.34 |
| ▸ | HCK | P08631 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 4/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 4/20 | 0.32 |
| ▸ | SIK3 | Q9Y2K2 | 4/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | DCAF15 | Q66K64 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25422139 | 1.00 | LCK (0.39) | LCKPTAFRSRCHCKPTPN11 | |
| SCHEMBL29536566 | 0.89 | LCK (0.33) | LCKMAP4K4 | |
| SCHEMBL25421994 | 0.89 | LCK (0.33) | LCKMAP4K4 | |
| SCHEMBL26075409 | 0.87 | LCK (0.33) | LCKMAP4K4 | |
| SCHEMBL29536947 | 0.85 | PSEN1 (0.33) | LCKPTAFRSRCHCKPAK1 | |
| SCHEMBL26075195 | 0.85 | PSEN1 (0.33) | LCKPTAFRSRCHCKPAK1 | |
| SCHEMBL29536415 | 0.84 | LCK (0.36) | LCKPTAFRPAK1 | |
| SCHEMBL25421619 | 0.84 | LCK (0.36) | LCKPTAFRPAK1 | |
| SCHEMBL25421226 | 0.83 | LCK (0.38) | LCKPTAFRSRCHCKPTPN11 | |
| SCHEMBL29537336 | 0.83 | LCK (0.38) | LCKPTAFRSRCHCKPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710453-A | Kinase inhibitors and uses thereof | 璧辰医药技术股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032071-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |