Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 5/20 | 0.43 |
| ▸ | CTSC | P53634 | 2/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.41 |
| ▸ | AXL | P30530 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250603 | 1.00 | GSK3B (0.47) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL24392985 | 0.88 | JAK3 (0.50) | KDRAURKBMERTKCTSCDDR2 | |
| SCHEMBL29537886 | 0.85 | SYK (0.43) | SYKKDRAURKBMERTKDDR2 | |
| SCHEMBL29537619 | 0.85 | MERTK (0.45) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL29537654 | 0.83 | LRRK2 (0.47) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL29250735 | 0.83 | LRRK2 (0.47) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL29250586 | 0.81 | MERTK (0.44) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL29537335 | 0.81 | MERTK (0.44) | GSK3BDYRK1ASYKKDRAURKB | |
| SCHEMBL24393252 | 0.80 | JAK3 (0.45) | SYKMERTKTYRO3AXLJAK2 | |
| SCHEMBL24393097 | 0.79 | DDR2 (0.47) | KDRAURKBMERTKDDR2TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |