Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29538268 | 0.95 | JAK3 (0.46) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| SCHEMBL24393006 | 0.95 | JAK3 (0.46) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| Trifluoroacetic Acid SCHEMBL29251056 | 0.92 | JAK3 (0.44) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| Trifluoroacetic Acid SCHEMBL29537456 | 0.92 | JAK3 (0.44) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| Pebezertinib SCHEMBL29538037 | 0.88 | JAK3 (0.49) | JAK3MAP3K7FGFR1SRCKDR | |
| SCHEMBL24392933 | 0.88 | JAK3 (0.43) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| SCHEMBL24392953 | 0.87 | JAK3 (0.43) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| SCHEMBL24392943 | 0.87 | JAK3 (0.51) | JAK3MAP3K7FGFR1SRCMAPK3 | |
| SCHEMBL24392821 | 0.87 | JAK2 (0.43) | JAK3MAP3K7FGFR1SRCKDR | |
| SCHEMBL29537579 | 0.87 | JAK2 (0.43) | JAK3MAP3K7FGFR1SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |