Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.61 |
| ▸ | JAK3 | P52333 | 9/20 | 0.61 |
| ▸ | BTK | Q06187 | 6/20 | 0.61 |
| ▸ | ITK | Q08881 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | BMX | P51813 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250579 | 1.00 | EGFR (0.61) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29538050 | 0.92 | EGFR (0.61) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29250650 | 0.92 | EGFR (0.61) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL24392850 | 0.89 | EGFR (0.61) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29537576 | 0.89 | EGFR (0.61) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL24392976 | 0.89 | EGFR (0.63) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29538534 | 0.89 | EGFR (0.63) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29251051 | 0.89 | EGFR (0.59) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL29538100 | 0.89 | EGFR (0.59) | EGFRJAK3BTKITKJAK2 | |
| SCHEMBL24388382 | 0.89 | JAK3 (0.62) | EGFRJAK3BTKITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |