Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | JAK3 | P52333 | 16/20 | 0.69 |
| ▸ | BTK | Q06187 | 10/20 | 0.69 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.59 |
| ▸ | TTK | P33981 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392701 | 1.00 | MAP3K7 (0.71) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL24392718 | 0.90 | MAP3K7 (0.71) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL29537572 | 0.89 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL29537573 | 0.89 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL24392702 | 0.89 | MAP3K7 (0.65) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL24392896 | 0.89 | MAP3K7 (0.68) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL29508118 | 0.89 | JAK3 (0.62) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL24388573 | 0.89 | JAK3 (0.62) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL24392724 | 0.88 | JAK3 (0.65) | MAP3K7MAP2K1MAPK1JAK3BTK | |
| SCHEMBL29538472 | 0.88 | JAK3 (0.65) | MAP3K7MAP2K1MAPK1JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |