Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | MERTK | Q12866 | 5/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24392761 | 1.00 | JAK3 (0.58) | JAK3EGFRMERTKMAP3K7MAPK1 | |
| Pebezertinib SCHEMBL24392854 | 0.94 | JAK3 (0.54) | JAK3EGFRMERTKMAP3K7MAPK1 | |
| Pebezertinib SCHEMBL29537331 | 0.89 | JAK3 (0.49) | JAK3EGFRMAP3K7FGFR1SRC | |
| Pebezertinib SCHEMBL29538037 | 0.89 | JAK3 (0.49) | JAK3MERTKMAP3K7FGFR1SRC | |
| SCHEMBL24392985 | 0.88 | JAK3 (0.50) | JAK3EGFRMERTKMAP3K7MAPK1 | |
| SCHEMBL24392974 | 0.88 | EGFR (0.57) | JAK3EGFRMERTKTYRO3DDR2 | |
| SCHEMBL29538169 | 0.88 | EGFR (0.57) | JAK3EGFRMERTKTYRO3DDR2 | |
| SCHEMBL24392710 | 0.88 | JAK3 (0.53) | JAK3EGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24393004 | 0.88 | JAK3 (0.54) | JAK3EGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL24392817 | 0.87 | MERTK (0.49) | JAK3EGFRMERTKMAP3K7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237418-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094354-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |