Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | EIF2AK4 | Q9P2K8 | 7/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546556 | 0.87 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1PIK3R1PIK3CAEIF2AK4 | |
| SCHEMBL23416942 | 0.73 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1PIK3R1PIK3CAEIF2AK4 | |
| SCHEMBL29797739 | 0.73 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1PIK3R1PIK3CAEIF2AK4 | |
| SCHEMBL21074037 | 0.72 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1PIK3R1PIK3CAATR | |
| SCHEMBL29546690 | 0.69 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1PIK3R1PIK3CAATR | |
| SCHEMBL29546718 | 0.69 | KDM4C (0.36) | SYKKMO | |
| SCHEMBL21823771 | 0.68 | S1PR1 (0.40) | HRH3 | |
| SCHEMBL24554242 | 0.68 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1PIK3R1PIK3CAATR | |
| SCHEMBL14923424 | 0.68 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1PIK3R1PIK3CAATR | |
| SCHEMBL29096122 | 0.68 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1PIK3R1PIK3CAATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860994-B1 | TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE | UNIV BRITISH COLUMBIA (CA) | 2024-08-14 | — | — | EP | disclosed |
| US-20220106304-A1 | Transcription Factor BRN2 Inhibitory Compounds as Therapeutics and Methods for Their Use | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2022-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106304-A1 | Transcription Factor BRN2 Inhibitory Compounds as Therapeutics and Methods for Their Use | BRDT, CBFB, CREBBP | HSP90AA1 2946/4885HSP90AB1 3173/4885PIK3R1 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.