Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.74 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.74 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18407354 | 0.88 | MAPK14 (0.81) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL66874 | 0.85 | MAPK14 (1.00) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL13235035 | 0.85 | MAPK14 (0.76) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2948759 | 0.83 | MAPK14 (0.80) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2959754 | 0.83 | MAPK14 (0.76) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2957650 | 0.83 | MAPK14 (0.73) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL5575739 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL2508762 | 0.81 | MAPK14 (0.80) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL9923555 | 0.81 | MAPK14 (0.84) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL9923556 | 0.81 | MAPK14 (1.00) | MAPK14MAPK13MAPK11MAPTMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767674-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767674-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767674-B2 | Kinase inhibitors | ELI LILLY AND COMPANY (US) | 2010-08-03 | — | — | US | disclosed |
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | ELI LILLY AND COMPANY (US) | 2008-12-11 | — | — | US | disclosed |
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | ELI LILLY AND COMPANY (US) | 2008-12-11 | — | — | US | disclosed |
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | ELI LILLY AND COMPANY (US) | 2008-12-11 | — | — | US | disclosed |
| EP-1761520-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2008-07-09 | — | — | EP | disclosed |
| EP-1761520-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006009741-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-01-26 | — | — | WO | disclosed |
| EP-1609789-A1 | UREIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306068-A1 | Suppression cytokines, tumor necrosis factor | TNF, TNFRSF1A, IL2 | MAPK14 436/4885MAPK13 576/4885MAPK11 672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.