Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | IL2 | P60568 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27098853 | 1.00 | CRBN (0.54) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098721 | 0.91 | CRBN (0.53) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL29547410 | 0.91 | CRBN (0.53) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098772 | 0.90 | CRBN (0.52) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098787 | 0.89 | CRBN (0.58) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098821 | 0.88 | CRBN (0.56) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098779 | 0.88 | CRBN (0.53) | CRBNDDB1CCNCCDK8IRAK1 | |
| SCHEMBL27098727 | 0.84 | CRBN (0.54) | CRBNDDB1IRAK1IRAK4IRAK3 | |
| SCHEMBL23129006 | 0.84 | CRBN (0.51) | CRBNCCNCCDK8IRAK1NTRK3 | |
| SCHEMBL27098768 | 0.83 | CRBN (0.52) | CRBNDDB1CCNCCDK8IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954801-A | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114867727-B | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-114867727-A | TAU protein targeting compounds and related methods of use | 阿尔维纳斯运营股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| EP-3999182-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2022-05-25 | — | — | EP | disclosed |