Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23530000 | 1.00 | MAPK1 (0.54) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL30402493 | 0.86 | MAPK1 (0.56) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL361098 | 0.86 | MAPK1 (0.56) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL22119231 | 0.86 | MAPK1 (0.56) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL11375152 | 0.84 | MAPK1 (0.54) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL20423622 | 0.84 | MAPK1 (0.54) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL1173618 | 0.84 | MAPK1 (0.54) | MAPK1MAPTKDM4EL3MBTL1RAB9A | |
| SCHEMBL31620610 | 0.82 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1RAB9ADYRK1A | |
| SCHEMBL10270980 | 0.82 | MAPK1 (0.59) | MAPK1KDM4EL3MBTL1RAB9ADYRK1A | |
| SCHEMBL13466852 | 0.81 | MAPK1 (0.57) | MAPK1MAPTKDM4EL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302886-B | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-114302886-A | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-04-08 | — | — | CN | disclosed |