Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 0.73 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22775201 | 1.00 | GRIN2B (0.73) | GRIN2BGRIN1CYP2C9KCNH2CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL29550660 | 0.95 | GRIN2B (0.67) | GRIN2BGRIN1CYP2C9KCNH2CYP2C19 | |
| SCHEMBL29550729 | 0.91 | GRIN2B (0.71) | GRIN2BGRIN1 | |
| SCHEMBL22775427 | 0.91 | GRIN2B (0.71) | GRIN2BGRIN1 | |
| SCHEMBL22775584 | 0.88 | GRIN2B (0.60) | GRIN2BGRIN1 | |
| SCHEMBL22775906 | 0.87 | GRIN2B (0.70) | GRIN2B | |
| SCHEMBL29550913 | 0.87 | GRIN2B (0.70) | GRIN2B | |
| SCHEMBL22775605 | 0.87 | GRIN2B (0.74) | GRIN2BGRIN1 | |
| SCHEMBL29550464 | 0.87 | GRIN2B (0.74) | GRIN2BGRIN1 | |
| SCHEMBL22775848 | 0.85 | GRIN2B (0.72) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983075-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | claimed |
| EP-3983075-A1 | SUBSTITUTED PYRAZOLO-PYRIDINE AMIDES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |