Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tak-901. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB known ✓ | Q96GD4 | 2/20 | 1.00 |
| ▸ | FLT3 | P36888 | 2/20 | 1.00 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 1.00 |
| ▸ | STK3 | Q13188 | 2/20 | 1.00 |
| ▸ | MELK | Q14680 | 2/20 | 1.00 |
| ▸ | SLK | Q9H2G2 | 2/20 | 1.00 |
| ▸ | PLK4 | O00444 | 1/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 1.00 |
| ▸ | EPHB6 | O15197 | 1/20 | 1.00 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 1.00 |
| ▸ | STK16 | O75716 | 1/20 | 1.00 |
| ▸ | STK10 | O94804 | 1/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | NTRK1 | P04629 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
| ▸ | YES1 | P07947 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tak-901 SCHEMBL29478939 | 1.00 | FLT3 (1.00) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL645679 | 1.00 | FLT3 (1.00) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL29389353 | 1.00 | FLT3 (1.00) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2123148 | 0.99 | FLT3 (0.98) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL646980 | 0.99 | FLT3 (0.98) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2125658 | 0.98 | FLT3 (0.97) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2122890 | 0.98 | FLT3 (0.97) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2125119 | 0.98 | FLT3 (0.96) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2121299 | 0.96 | FLT3 (0.93) | FLT3RPS6KA3PRKAA1STK3MELK | |
| Tak-901 SCHEMBL2121923 | 0.96 | FLT3 (0.93) | FLT3RPS6KA3PRKAA1STK3MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116334024-A | Aurora kinase B gene K85 and K87 mutation and application thereof | 北京大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-116004567-A | Aurora kinase B gene K202 mutation and application thereof | 北京大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-107841532-B | Method for screening anti-breast cancer metastasis compound and application of related compound | 清华大学 | 2022-04-08 | — | — | CN | disclosed |