Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 12/20 | 0.46 |
| ▸ | JAK2 | O60674 | 11/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 5/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29552441 | 0.90 | JAK2 (0.48) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28359015 | 0.88 | TYK2 (0.44) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29922729 | 0.88 | TYK2 (0.44) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551945 | 0.84 | DHODH (0.41) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551959 | 0.83 | JAK2 (0.46) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29552942 | 0.82 | TYK2 (0.41) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28362708 | 0.82 | DHODH (0.45) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL28884120 | 0.81 | TYK2 (0.55) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29551923 | 0.81 | TYK2 (0.55) | TYK2JAK2JAK1JAK3DHODH | |
| SCHEMBL29552473 | 0.81 | JAK2 (0.44) | TYK2JAK2JAK1JAK3DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032484-A1 | PYRIDAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 北京诺诚健华医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |