Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19285441 | 1.00 | ABL1 (0.36) | ABL1KDM4CKDM1ASYKSCN9A | |
| SCHEMBL19285442 | 1.00 | ABL1 (0.36) | ABL1KDM4CKDM1ASYKSCN9A | |
| SCHEMBL23669554 | 0.93 | ABL1 (0.36) | ABL1KDM4CKDM1ASCN9ABACE1 | |
| SCHEMBL23669556 | 0.93 | ABL1 (0.36) | ABL1KDM4CKDM1ASCN9ABACE1 | |
| SCHEMBL29553798 | 0.93 | ABL1 (0.36) | ABL1KDM4CKDM1ASCN9ABACE1 | |
| SCHEMBL23671128 | 0.92 | KDM4C (0.37) | KDM4CKDM1ASCN9A | |
| SCHEMBL23670689 | 0.87 | KDM4C (0.37) | KDM4CKDM1A | |
| SCHEMBL19285180 | 0.87 | TDP1 (0.36) | KDM4CSYK | |
| SCHEMBL29552537 | 0.87 | TDP1 (0.36) | KDM4CSYK | |
| SCHEMBL19285181 | 0.87 | TDP1 (0.36) | KDM4CSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11306107-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2022-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11306107-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | ABL1 36/4885KDM4C 3483/4885KDM1A 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.