Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 19/20 | 0.81 |
| ▸ | TLR7 | Q9NYK1 | 18/20 | 0.81 |
| ▸ | TLR4 | O00206 | 2/20 | 0.81 |
| ▸ | TLR3 | O15455 | 2/20 | 0.81 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19838366 | 1.00 | TLR9 (0.81) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL19839195 | 0.90 | TLR9 (1.00) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL19850067 | 0.89 | TLR7 (0.79) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL29555563 | 0.89 | TLR9 (0.82) | TLR9TLR7TLR4TLR3TLR8 | |
| Hydrochloric Acid SCHEMBL19838783 | 0.89 | TLR9 (0.98) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL19838376 | 0.89 | TLR9 (0.78) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL19838706 | 0.89 | TLR9 (0.82) | TLR9TLR7TLR4TLR3TLR8 | |
| Hydrochloric Acid SCHEMBL29555536 | 0.89 | TLR9 (0.98) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL28725680 | 0.88 | TLR9 (0.78) | TLR9TLR7TLR4TLR3TLR8 | |
| SCHEMBL29555446 | 0.88 | TLR9 (1.00) | TLR9TLR7TLR4TLR3TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |