Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 19/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 18/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19850077 | 1.00 | TLR7 (0.42) | TLR7TLR9TLR8HRH3 | |
| SCHEMBL19850120 | 0.92 | TLR9 (0.46) | TLR7TLR9TLR8 | |
| SCHEMBL29555861 | 0.92 | TLR9 (0.46) | TLR7TLR9TLR8 | |
| SCHEMBL19839197 | 0.88 | TLR9 (0.44) | TLR7TLR9TLR8HRH3 | |
| SCHEMBL19838429 | 0.82 | TLR7 (0.47) | TLR7TLR9TLR8 | |
| SCHEMBL19839243 | 0.79 | TLR9 (0.50) | TLR7TLR9TLR8 | |
| SCHEMBL19839198 | 0.78 | TLR9 (0.49) | TLR7TLR9TLR8 | |
| SCHEMBL4564154 | 0.78 | HRH3 (0.43) | TLR7TLR9HRH3 | |
| SCHEMBL5805849 | 0.77 | HRH3 (0.45) | HRH3 | |
| SCHEMBL19849996 | 0.76 | TLR7 (0.69) | TLR7TLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |