Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 10/20 | 0.62 |
| ▸ | MET | P08581 | 4/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | TEK | Q02763 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.55 |
| ▸ | RET | P07949 | 4/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | PDXK | O00764 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | LYN | P07948 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890635 | 1.00 | AXL (0.65) | AXLKDRMETAURKBAURKA | |
| SCHEMBL23982910 | 0.90 | KDR (0.54) | AXLKDRMETAURKBAURKA | |
| SCHEMBL22106609 | 0.89 | AXL (0.70) | AXLKDRMETAURKBAURKA | |
| SCHEMBL1890374 | 0.89 | AXL (0.63) | AXLKDRMETAURKBAURKA | |
| SCHEMBL29073385 | 0.88 | AXL (0.59) | AXLKDRMETAURKBAURKA | |
| SCHEMBL12663554 | 0.88 | AXL (0.60) | AXLKDRMETAURKBAURKA | |
| SCHEMBL1890626 | 0.87 | KDR (0.70) | AXLKDRMETAURKBAURKA | |
| SCHEMBL12501921 | 0.87 | AXL (0.62) | AXLKDRMETAURKBAURKA | |
| SCHEMBL22505692 | 0.86 | KDR (0.60) | AXLKDRMETAURKBAURKA | |
| SCHEMBL1132598 | 0.86 | AXL (0.62) | AXLKDRMETAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452947-A1 | CRYSTALLINE FORMS AND SALT FORMS OF A KINASE INHIBITOR | Exelixis, Inc. (US) | 2024-10-30 | — | — | EP | disclosed |
| CN-118647603-A | Crystalline forms and salt forms of kinase inhibitors | 埃克塞里艾克西斯公司 | 2024-09-13 | — | — | CN | disclosed |
| EP-4426678-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | Exelixis, Inc. (US) | 2024-09-11 | — | — | EP | disclosed |
| CN-118176182-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-117820226-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-117624045-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117603138-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117402114-A | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-111757735-B | Compounds for the treatment of kinase dependent disorders | 埃克塞里艾克西斯公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-4240333-A1 | PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR | Exelixis, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2023122739-A1 | CRYSTALLINE FORMS AND SALT FORMS OF A KINASE INHIBITOR | EXELIXIS, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023081253-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| EP-4143169-A1 | PROCESSES FOR THE PREPARATION OF A KINASE INHIBITOR | Exelixis, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-115461328-A | Process for preparing kinase inhibitors | 埃克塞里艾克西斯公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-114853746-A | Formamide compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-114787144-A | Pyridone compounds and methods for modulating protein kinases | 埃克塞里艾克西斯公司 | 2022-07-22 | — | — | CN | disclosed |
| WO-2022098828-A1 | PHARMACEUTICAL COMPOSITIONS OF A KINASE INHIBITOR | EXELIXIS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |