Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 17/20 | 0.58 |
| ▸ | PRKDC | P78527 | 10/20 | 0.58 |
| ▸ | ATR | Q13535 | 12/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.43 |
| ▸ | MTOR | P42345 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21541830 | 1.00 | ATM (0.58) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL29559109 | 0.88 | ATM (0.63) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL21541883 | 0.88 | ATM (0.63) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL21541794 | 0.87 | ATM (0.62) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL30359526 | 0.87 | ATM (0.62) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL21541879 | 0.84 | PRKDC (0.81) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL30359521 | 0.84 | PRKDC (0.81) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL23093848 | 0.82 | ATM (0.61) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL21541760 | 0.79 | PRKDC (0.73) | ATMPRKDCATRPIK3CBMTOR | |
| SCHEMBL21541772 | 0.76 | PRKDC (0.77) | ATMPRKDCATRPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567041-B1 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | IMPACT THERAPEUTICS SHANGHAI INC (CN) | 2023-12-27 | — | — | EP | disclosed |
| EP-3567041-A9 | SUBSTITUTED FUSED HETEROARYL COMPOUND SERVING AS A KINASE INHIBITOR, AND APPLICATIONS THEREOF | Impact Therapeutics (Shanghai), Inc (CN) | 2022-04-20 | — | — | EP | disclosed |