SCHEMBL29560111

SCHEMBL29560111

CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(N4CCN(C)CC4)c(C#N)c3c2=O)c2scc(C(=O)OC(C)(C)C)c2n1

nearest known ligand 0.86

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.86

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22866598 0.94 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL28704403 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29560441 0.91 EIF4EBP1 (0.75) EIF4EBP1
SCHEMBL29661943 0.87 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL22866553 0.87 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL29650419 0.86 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866774 0.84 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866523 0.84 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560096 0.84 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560206 0.84 EIF4EBP1 (0.84) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114269756-B 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E 效应疗法股份有限公司 2024-05-14 — — CN disclosed
CN-114269756-A 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E 效应疗法股份有限公司 2022-04-01 — — CN disclosed
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