Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21063708 | 1.00 | PRCP (0.65) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL21063727 | 1.00 | PRCP (0.65) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL30444018 | 1.00 | PRCP (0.65) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL27928028 | 0.85 | PRCP (0.65) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL31632627 | 0.84 | PRCP (0.44) | PRCPMEN1KMT2AHTR2AHTR2C | |
| SCHEMBL27910413 | 0.83 | PRCP (0.63) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL23274866 | 0.82 | PRCP (0.61) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL29924130 | 0.82 | PRCP (0.61) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL29924153 | 0.81 | PRCP (0.69) | PRCPGAAMEN1KMT2ARECQL | |
| SCHEMBL23274901 | 0.81 | PRCP (0.69) | PRCPGAAMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113950477-B | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-116997547-A | Granulin precursor modulators and methods of use thereof | 阿库达医疗公司 | 2023-11-03 | — | — | CN | disclosed |
| US-20220251084-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | JANSSEN PHARMACEUTICA NV (BE) | 2022-08-11 | — | — | US | disclosed |
| EP-3983401-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | Arkuda Therapeutics (US) | 2022-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251084-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | GRN, PRNP, PSEN2 | PRCP 62/4885GAA 277/4885MEN1 1138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.