Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.54 |
| ▸ | BMX | P51813 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | YES1 | P07947 | 2/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.54 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561736 | 0.93 | SRC (0.57) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL21611719 | 0.89 | SRC (0.72) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL30986315 | 0.89 | SRC (0.72) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL29562844 | 0.87 | SRC (0.62) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL21614412 | 0.83 | SRC (0.79) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL23111982 | 0.82 | SRC (0.73) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL23111946 | 0.82 | SRC (0.73) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL21614411 | 0.81 | SRC (0.75) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL23111945 | 0.81 | SRC (0.69) | SRCNTRK1BMXABL1YES1 | |
| SCHEMBL23111944 | 0.81 | SRC (0.69) | SRCNTRK1BMXABL1YES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110194772-B | Alkynyl (hetero) aromatic ring compounds for inhibiting protein kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2022-04-05 | — | — | CN | disclosed |