Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22832046 | 1.00 | BRAF (0.43) | BRAFCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL29561750 | 0.87 | BRAF (0.46) | BRAFCYP2C9KCNH2PTGES2 | |
| SCHEMBL22832003 | 0.87 | BRAF (0.46) | BRAFCYP2C9KCNH2PTGES2 | |
| SCHEMBL1492043 | 0.82 | BRAF (0.43) | BRAFCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL9930698 | 0.77 | BRAF (0.44) | BRAFCYP2C9 | |
| SCHEMBL22831933 | 0.74 | BRAF (0.46) | BRAFCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL29562097 | 0.74 | BRAF (0.46) | BRAFCYP3A4CYP2C9CYP2C19KCNH2 | |
| SCHEMBL22832009 | 0.71 | BRAF (0.45) | BRAFKCNH2 | |
| SCHEMBL29561872 | 0.71 | BRAF (0.48) | BRAFCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22832075 | 0.71 | BRAF (0.48) | BRAFCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026073-B | Quinazolin-4-one derivatives for the treatment of BRAF related diseases and disorders | ARRAY生物制药公司 | 2024-08-23 | — | — | CN | disclosed |
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |