⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22831867 | 1.00 | — | — | |
| SCHEMBL22831974 | 0.86 | ALOX5AP (0.32) | — | |
| SCHEMBL22832115 | 0.85 | ALOX5AP (0.31) | — | |
| SCHEMBL20840395 | 0.83 | BRAF (0.31) | — | |
| SCHEMBL29561667 | 0.80 | — | — | |
| SCHEMBL22831908 | 0.80 | — | — | |
| SCHEMBL22831981 | 0.78 | — | — | |
| SCHEMBL22832008 | 0.78 | ALOX5AP (0.32) | — | |
| SCHEMBL22831990 | 0.77 | ALOX5AP (0.31) | — | |
| SCHEMBL22831845 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026073-B | Quinazolin-4-one derivatives for the treatment of BRAF related diseases and disorders | ARRAY生物制药公司 | 2024-08-23 | — | — | CN | disclosed |
| EP-3990437-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | Array Biopharma, Inc. (US) | 2022-05-04 | — | — | EP | disclosed |