Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562864 | 1.00 | TYK2 (0.58) | TYK2JAK2JAK1NOTUMALOX5 | |
| SCHEMBL29563338 | 0.92 | TYK2 (0.69) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29562969 | 0.92 | TYK2 (0.69) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29563038 | 0.91 | TYK2 (0.51) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29563702 | 0.91 | TYK2 (0.51) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29562697 | 0.89 | TYK2 (0.63) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29562660 | 0.85 | TYK2 (0.53) | TYK2JAK2JAK1 | |
| SCHEMBL29563116 | 0.85 | TYK2 (0.53) | TYK2JAK2JAK1 | |
| SCHEMBL29563085 | 0.85 | TYK2 (0.53) | TYK2JAK2JAK1 | |
| SCHEMBL29562916 | 0.85 | TYK2 (0.52) | TYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109580-A1 | INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-27 | — | — | WO | disclosed |