Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.30 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.30 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.30 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563039 | 1.00 | TYK2 (0.59) | TYK2JAK2JAK1MTORRICTOR | |
| SCHEMBL29563074 | 0.89 | TYK2 (0.72) | TYK2JAK2JAK1 | |
| SCHEMBL29563122 | 0.89 | TYK2 (0.72) | TYK2JAK2JAK1 | |
| SCHEMBL29562928 | 0.85 | TYK2 (0.82) | TYK2JAK2JAK1 | |
| SCHEMBL29563240 | 0.85 | TYK2 (0.82) | TYK2JAK2JAK1 | |
| SCHEMBL29562590 | 0.85 | TYK2 (0.47) | TYK2JAK2JAK1MTOR | |
| SCHEMBL29562696 | 0.85 | TYK2 (0.47) | TYK2JAK2JAK1MTOR | |
| SCHEMBL29563007 | 0.84 | TYK2 (0.71) | TYK2JAK2JAK1MTOR | |
| SCHEMBL29563133 | 0.84 | TYK2 (0.71) | TYK2JAK2JAK1MTOR | |
| SCHEMBL29563121 | 0.84 | TYK2 (0.65) | TYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109580-A1 | INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-27 | — | — | WO | disclosed |