Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.69 |
| ▸ | JAK2 | O60674 | 3/20 | 0.69 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562640 | 1.00 | TYK2 (0.69) | TYK2JAK2JAK1CYP3A4ADORA2A | |
| SCHEMBL29563006 | 0.93 | TYK2 (0.80) | TYK2JAK2JAK1 | |
| SCHEMBL29563185 | 0.93 | TYK2 (0.80) | TYK2JAK2JAK1 | |
| SCHEMBL29562814 | 0.90 | TYK2 (0.67) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29563088 | 0.90 | TYK2 (0.67) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29562918 | 0.89 | TYK2 (0.66) | TYK2JAK2JAK1 | |
| SCHEMBL29563732 | 0.89 | TYK2 (0.86) | TYK2JAK2JAK1PIK3CA | |
| SCHEMBL29562770 | 0.85 | TYK2 (0.57) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29562777 | 0.85 | TYK2 (0.57) | TYK2JAK2JAK1ALOX5 | |
| SCHEMBL29563133 | 0.85 | TYK2 (0.71) | TYK2JAK2JAK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109580-A1 | INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-27 | — | — | WO | disclosed |