Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 16/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562838 | 1.00 | TYK2 (0.66) | TYK2JAK2JAK1ABL1GCK | |
| SCHEMBL29563023 | 0.93 | TYK2 (0.76) | TYK2JAK2JAK1ABL1GCK | |
| SCHEMBL29563758 | 0.93 | TYK2 (0.76) | TYK2JAK2JAK1ABL1GCK | |
| SCHEMBL29563732 | 0.87 | TYK2 (0.86) | TYK2JAK2JAK1 | |
| SCHEMBL29562760 | 0.85 | TYK2 (0.55) | TYK2JAK2JAK1 | |
| SCHEMBL29562768 | 0.85 | TYK2 (0.55) | TYK2JAK2JAK1 | |
| SCHEMBL29562660 | 0.84 | TYK2 (0.53) | TYK2JAK2JAK1 | |
| SCHEMBL29563116 | 0.84 | TYK2 (0.53) | TYK2JAK2JAK1 | |
| SCHEMBL29562888 | 0.84 | TYK2 (0.63) | TYK2JAK2JAK1ABL1 | |
| SCHEMBL29563335 | 0.84 | TYK2 (0.63) | TYK2JAK2JAK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109580-A1 | INHIBITION OF TYK2 DEPENDENT SIGNALING PATHWAYS | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-27 | — | — | WO | disclosed |