Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675343 | 1.00 | HPGD (0.56) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL30201394 | 0.88 | HPGD (0.61) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL29564747 | 0.88 | HPGD (0.61) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL23675344 | 0.88 | HPGD (0.61) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL24942913 | 0.88 | HPGD (0.61) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL23675308 | 0.86 | HPGD (0.55) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL29564736 | 0.86 | HPGD (0.55) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL23675306 | 0.86 | HPGD (0.55) | HPGDMGLLDDR1CYP3A4CYP1A2 | |
| SCHEMBL29141081 | 0.85 | HPGD (0.52) | HPGDMGLLDDR1VNN1 | |
| SCHEMBL23675325 | 0.84 | HPGD (0.57) | HPGDMGLLDDR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335043-B | PGDH inhibitors and methods of making and using the same | 迈欧伏特治疗公司 | 2025-03-28 | — | — | CN | disclosed |
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |