Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675203 | 1.00 | HPGD (0.54) | HPGDMGLLLRRK2HTR1AVNN1 | |
| SCHEMBL23675180 | 0.89 | HPGD (0.58) | HPGDMGLLLRRK2VNN1 | |
| SCHEMBL23680762 | 0.89 | HPGD (0.57) | HPGDMGLLLRRK2HTR1AVNN1 | |
| SCHEMBL29565007 | 0.88 | HPGD (0.57) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL29564917 | 0.88 | HPGD (0.51) | HPGDMGLLLRRK2VNN1DDR1 | |
| SCHEMBL23675129 | 0.88 | HPGD (0.51) | HPGDMGLLLRRK2VNN1DDR1 | |
| SCHEMBL23675325 | 0.88 | HPGD (0.57) | HPGDMGLLLRRK2DDR1 | |
| SCHEMBL23675113 | 0.85 | HPGD (0.54) | HPGDMGLLLRRK2HTR1AVNN1 | |
| SCHEMBL23675112 | 0.85 | HPGD (0.54) | HPGDMGLLLRRK2VNN1DDR1 | |
| SCHEMBL23675181 | 0.84 | HPGD (0.53) | HPGDMGLLLRRK2VNN1DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |