Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675221 | 1.00 | HPGD (0.53) | HPGDRECQLGRM5ALDH1A1CA12 | |
| SCHEMBL24942775 | 1.00 | HPGD (0.53) | HPGDRECQLGRM5ALDH1A1CA12 | |
| SCHEMBL23675222 | 1.00 | HPGD (0.53) | HPGDRECQLGRM5ALDH1A1CA12 | |
| SCHEMBL24463707 | 0.94 | HPGD (0.50) | HPGDRECQLGRM5ALDH1A1MGLL | |
| SCHEMBL23680632 | 0.94 | HPGD (0.50) | HPGDRECQLGRM5ALDH1A1MGLL | |
| SCHEMBL29565726 | 0.91 | HPGD (0.50) | HPGDRECQLGRM5ALDH1A1CA12 | |
| SCHEMBL29257187 | 0.89 | HPGD (0.50) | HPGDRECQLGRM5ALDH1A1MGLL | |
| SCHEMBL24942223 | 0.89 | HPGD (0.50) | HPGDRECQLGRM5ALDH1A1MGLL | |
| SCHEMBL23680629 | 0.87 | HPGD (0.67) | HPGDGRM5ALDH1A1MGLL | |
| SCHEMBL29257221 | 0.86 | HPGD (0.56) | HPGDRECQLGRM5ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228650-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | Epirium Bio Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4093385-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | Myoforte Therapeutics Inc. (US) | 2022-11-30 | — | — | EP | disclosed |
| WO-2022082009-A1 | INHALED FORMULATIONS OF PGDH INHIBITORS AND METHODS OF USE THEREOF | EPIRIUM BIO INC. (US) | 2022-04-21 | — | — | WO | disclosed |