Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25890280 | 1.00 | PARP1 (0.43) | PARP1ARHDAC6PRMT5WDR77 | |
| SCHEMBL25315024 | 1.00 | PARP1 (0.43) | PARP1ARHDAC6PRMT5WDR77 | |
| SCHEMBL30132743 | 0.97 | PARP1 (0.43) | PARP1ARPRMT5WDR77 | |
| SCHEMBL25312615 | 0.97 | PARP1 (0.43) | PARP1ARPRMT5WDR77 | |
| SCHEMBL30132750 | 0.93 | PARP1 (0.40) | PARP1HDAC6PRMT5WDR77 | |
| SCHEMBL25316173 | 0.93 | PARP1 (0.40) | PARP1HDAC6PRMT5WDR77 | |
| SCHEMBL25312643 | 0.93 | PARP1 (0.40) | PARP1HDAC6PRMT5WDR77 | |
| SCHEMBL25890284 | 0.93 | PARP1 (0.40) | PARP1HDAC6PRMT5WDR77 | |
| SCHEMBL30132752 | 0.93 | PARP1 (0.40) | PARP1HDAC6PRMT5WDR77 | |
| SCHEMBL24390137 | 0.91 | PARP1 (0.48) | PARP1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143182-B1 | NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2024-12-11 | — | — | EP | claimed |
| EP-4143182-A1 | NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | Rhizen Pharmaceuticals AG (CH) | 2023-03-08 | — | — | EP | claimed |
| CN-115485271-A | Novel compounds as inhibitors of poly (ADP-ribose) polymerase (PARP) | 理森制药股份公司 | 2022-12-16 | — | — | CN | claimed |
| EP-4143182-A1 | NOVEL COMPOUNDS USEFUL AS POLY(ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS | Rhizen Pharmaceuticals AG (CH) | 2023-03-08 | — | — | EP | disclosed |
| CN-115485271-A | Novel compounds as inhibitors of poly (ADP-ribose) polymerase (PARP) | 理森制药股份公司 | 2022-12-16 | — | — | CN | disclosed |
| WO-2022090938-A1 | PHTHALAZINONE DERIVATIVES USEFUL AS PARP INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2022-05-05 | — | — | WO | disclosed |