Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.56 |
| ▸ | JAK3 | P52333 | 20/20 | 0.56 |
| ▸ | JAK2 | O60674 | 15/20 | 0.56 |
| ▸ | JAK1 | P23458 | 15/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.47 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19469211 | 1.00 | TYK2 (0.56) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL19469209 | 1.00 | TYK2 (0.56) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL29707880 | 1.00 | TYK2 (0.56) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL19469215 | 0.97 | JAK3 (0.59) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL19469214 | 0.97 | JAK3 (0.59) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL29565830 | 0.97 | JAK3 (0.59) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL30930692 | 0.97 | JAK3 (0.59) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL18260560 | 0.95 | TYK2 (0.54) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL18260557 | 0.95 | TYK2 (0.54) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21569472 | 0.93 | JAK3 (0.58) | TYK2JAK3JAK2JAK1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |