Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.75 |
| ▸ | JAK3 | P52333 | 20/20 | 0.75 |
| ▸ | JAK2 | O60674 | 15/20 | 0.75 |
| ▸ | JAK1 | P23458 | 15/20 | 0.75 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.64 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18269689 | 1.00 | TYK2 (0.75) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL29512168 | 1.00 | TYK2 (0.75) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL26323063 | 0.97 | JAK3 (0.78) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL18260446 | 0.89 | TYK2 (0.82) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL18260449 | 0.89 | TYK2 (0.82) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL23878845 | 0.88 | TYK2 (0.58) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL22054114 | 0.88 | TYK2 (0.58) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL31304735 | 0.88 | TYK2 (0.58) | TYK2JAK3JAK2JAK1P2RX3 | |
| SCHEMBL21574333 | 0.86 | TYK2 (0.79) | TYK2JAK3JAK2JAK1 | |
| SCHEMBL19469201 | 0.86 | TYK2 (0.79) | TYK2JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116368134-A | Methods of making ubiquitin JAK inhibitors and related intermediate compounds | 施万生物制药研发IP有限责任公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-111362975-B | Naphthyridine compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2022-04-05 | — | — | CN | disclosed |