Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29565975 | 0.93 | PARP1 (0.59) | PARP1LMNA | |
| SCHEMBL25890319 | 0.90 | PARP1 (0.70) | PARP1LMNACYP3A4CYP2C9TSHR | |
| SCHEMBL30132749 | 0.90 | PARP1 (0.70) | PARP1LMNACYP3A4CYP2C9TSHR | |
| SCHEMBL29566443 | 0.89 | PARP1 (0.68) | PARP1 | |
| SCHEMBL29565339 | 0.89 | PARP1 (0.70) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL24390012 | 0.89 | PARP1 (0.70) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL25890272 | 0.89 | PARP1 (0.68) | PARP1 | |
| SCHEMBL25890631 | 0.86 | PARP1 (0.65) | PARP1CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL24390023 | 0.85 | PARP1 (0.64) | PARP1 | |
| SCHEMBL29566305 | 0.84 | PARP1 (0.49) | PARP1LMNACYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022090938-A1 | PHTHALAZINONE DERIVATIVES USEFUL AS PARP INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2022-05-05 | — | — | WO | disclosed |