Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26651235 | 1.00 | PIK3CG (0.38) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL24309239 | 0.87 | CCNT1 (0.40) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL24309349 | 0.86 | PIK3CG (0.42) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL26806550 | 0.85 | TSHR (0.39) | PIK3CGPIK3CDPIK3CBMTORTSHR | |
| SCHEMBL24310735 | 0.85 | PIK3CD (0.39) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL24309545 | 0.84 | TSHR (0.40) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL26806587 | 0.84 | TSHR (0.40) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL26806586 | 0.83 | TSHR (0.42) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL24310769 | 0.83 | EGFR (0.44) | PIK3CGPIK3CDPIK3CBMTOREGFR | |
| SCHEMBL24310345 | 0.83 | TSHR (0.43) | PIK3CGPIK3CDPIK3CBMTOREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |